Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy
نویسندگان
چکیده
منابع مشابه
Effects of UGT1A3, UGT1A6, and UGT2B7 genetic polymorphisms on plasma concentration of valproic acid in south Chinese epilepsy patients
Valproic acid (VPA) is one of the most commonly used anti-epileptic drugs in epilepsy patients. The large interindividual variability in plasma VPA concentration may reflect functional consequence of genetic polymorphisms in genes encoding drug-metabolizing enzymes, especially uridine 5’-diphospho (UDP)-glucuronosyltransferase (UGT). This study was aimed to determine the relationship between pl...
متن کاملEffect of UGT2B7 genetic variants on serum valproic acid concentration.
OBJECTIVE To investigate the effect of UGT2B7 A268G and UGT2B7 G211T genetic polymorphism on serum drug concentration of valproic acid (VPA). METHODS Genetic polymorphisms of UGT2B7 A268G and UGT2B7 G211T were tested in 248 epileptic patients by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Data including basic information, epilepsy type, times and doses of dr...
متن کاملTherapeutic Drug Monitoring of Valproic Acid in Patients with Monotherapy at Steady State
Objective(s) The role of therapeutic drug monitoring (TDM) in patient care has grown rapidly since its introduction three decades ago. The aim of present study was to evaluate the possible relationship between serum levels and the clinical response of valproic acid (VPA). Materials and Methods In the present study we evaluated a homogeneous group of adult patients receiving VPA monotherapy. ...
متن کاملVALPROIC ACID- valproic acid solution Par Pharmaceutical ----------
WARNINGS: LIFE THREATENING ADVERSE REACTIONS See full prescribing information for complete boxed warning. Hepato toxicity, including fatalities, usually during first 6 months o f treatment. Children under the age of two years and patients with mitochondrial disorders are at higher risk. Monitor patients c losely, and perform serum liver testing prior to therapy and at frequent intervals thereaf...
متن کاملPseudoatrophy of the brain with valproic acid monotherapy.
A patient is described who, while on valproic acid monotherapy, developed reversible shrinkage of the brain, documented by computerized tomography with associated cognitive deficit. Although pseudoatrophy has been reported with steroid therapy, this is the first implication of an anticonvulsant drug in the etiology of that condition.
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ژورنال
عنوان ژورنال: Seizure
سال: 2017
ISSN: 1059-1311
DOI: 10.1016/j.seizure.2017.07.005